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Figure 8 To conclude, macrocyclizations by oxidative disulfide formations in the N-terminal of Ang IV analogues or alternatively displacement of the disulfide unite with a trans double bond can provide very potent inhibitors of IRAP, as exemplified with 23 (HA08) comprising a 13-membered ring system and 28 , 30 , and 32 comprising 14-membered ring systems

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Protocol 1: standard longevity cycle Goal: General anti-aging and telomere maintenance Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 5 mg epitalon subcutaneously, once daily at bedtime Days 21-180: Off cycle, no epitalon Repeat cycle 1-2 times per year Reconstitution: 10 mg vial plus 2 mL bacteriostatic water equals 5 mg/mL